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15-11-2015, 03:29 PM
Tackling Vit D deficiency can help patients with chronic kidney disease
Correction of Vitamin D deficiency can significantly help patients with chronic kidney disease as it helps prevent the development of cardiovascular diseases, according to a new study.
Nutritional Vitamin D supplementation improves vascular function and reduces inflammation in patients with early stage chronic kidney disease, according to a study by researchers from the George Institute for Global Health, New Delhi, and the Postgraduate Institute of Medical Education and Research, Chandigarh.
The study was presented at the American Society of Nephrology Kidney Week 2015, held between November 3 and November 8 in San Diego. “About one in 10 people suffer from chronic kidney disease across the globe. Most of them are destined to develop premature cardiovascular disease, hence mitigation of this risk is an important therapeutic goal,” pointed out Professor Vivekanand Jha, the leader of the group that did the study.
‘Vitamin D deficiency is common in patients with chronic kidney disease. Our study shows that simply identifying and correcting this abnormality has the potential to improve the outcomes in these patients,” said Dr Vivek Kumar, nephrologist, PGI, Chandigarh and the first author of the study.
In a randomised controlled trial, the researchers gave two doses of 300,000 units of Vitamin D to one group of patients eight weeks apart, whereas the patients in the other group received matching placebos. Several parameters of vascular function and biomarkers to measure the status of inflammatory and immune activation were studied at baseline as well as after 16 weeks.
It was found that levels of Vitamin D increased in patients in the active treatment group, whereas there was no change in the placebo arm. Nearly 70 per cent of patients receiving Vitamin D demonstrated significant improvement in their vascular functions and improvement in biomarkers, indicating reduction in the level of inflammatory and immune activation. In the placebo arm, only 5 per cent patients showed improved vascular function and there was no change in the inflammatory and immune markers. Neither the patients nor the study doctors were aware of which patients received which treatment till the end.
“Vitamin D is cheap and widely available, and through its favourable effects on inflammatory and immune functions, has the potential to favourably influence the course of these patients. This study has shown improvement in a range of parameters in Vitamin-D treated patients,” said Dr Jha.
Correction of Vitamin D deficiency can significantly help patients with chronic kidney disease as it helps prevent the development of cardiovascular diseases, according to a new study.
Nutritional Vitamin D supplementation improves vascular function and reduces inflammation in patients with early stage chronic kidney disease, according to a study by researchers from the George Institute for Global Health, New Delhi, and the Postgraduate Institute of Medical Education and Research, Chandigarh.
The study was presented at the American Society of Nephrology Kidney Week 2015, held between November 3 and November 8 in San Diego. “About one in 10 people suffer from chronic kidney disease across the globe. Most of them are destined to develop premature cardiovascular disease, hence mitigation of this risk is an important therapeutic goal,” pointed out Professor Vivekanand Jha, the leader of the group that did the study.
‘Vitamin D deficiency is common in patients with chronic kidney disease. Our study shows that simply identifying and correcting this abnormality has the potential to improve the outcomes in these patients,” said Dr Vivek Kumar, nephrologist, PGI, Chandigarh and the first author of the study.
In a randomised controlled trial, the researchers gave two doses of 300,000 units of Vitamin D to one group of patients eight weeks apart, whereas the patients in the other group received matching placebos. Several parameters of vascular function and biomarkers to measure the status of inflammatory and immune activation were studied at baseline as well as after 16 weeks.
It was found that levels of Vitamin D increased in patients in the active treatment group, whereas there was no change in the placebo arm. Nearly 70 per cent of patients receiving Vitamin D demonstrated significant improvement in their vascular functions and improvement in biomarkers, indicating reduction in the level of inflammatory and immune activation. In the placebo arm, only 5 per cent patients showed improved vascular function and there was no change in the inflammatory and immune markers. Neither the patients nor the study doctors were aware of which patients received which treatment till the end.
“Vitamin D is cheap and widely available, and through its favourable effects on inflammatory and immune functions, has the potential to favourably influence the course of these patients. This study has shown improvement in a range of parameters in Vitamin-D treated patients,” said Dr Jha.
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